The New York Times suggests my legs are not tired -- rather my skeletal muscles have leaky calcium channels.
Although an "antifatigue" drug worked in mice, one doctor urged caution: "[W]e have to ask whether it would be prudent to . . . circumvent[] this mechanism. . . . Maybe this is a protective mechanism. . . . Maybe fatigue is saying that you are getting ready to go into a danger zone. So it is cutting you off. If you could will yourself to run as fast and as long as you could, some people would run until they keeled over and died."
I am far too soft to be in danger, but some people do not need drugs to push that hard. Although overexertion did not kill him, elite marathoner Ryan Shay comes to mind.
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